OUR PIPELINE

 
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We are developing small-molecule medicines, with clinically validated mechanisms of action, to address oncology and metabolic diseases with large unmet medical need.

MECHANISM PROGRAM INDICATION PRECLINICAL STATUS / NEXT MILESTONE EARLY STAGE CLINICAL DEVELOPMENT LATE STAGE CLINICAL DEVELOPMENT Ph1 CARDINAL ongoing TERN-701 CML TERN-800 Series GIPR Modulators Obesity Anticipated registrational trial following Ph 1 trial TERN-601 Obesity Oral GLP-1RAgonist Metabolic Oncology Obesity TERN-501 Combination THR- Agonist + PHASE 1 Phase 2 initiation 2025 Preclinical data in combo with GLP-1 (enhanced and higher quality weight) Positive Ph2a NASH data Phase 2 Ready GIPR AntagonistLead Opt. Metabolic Agent Phase 2 Ready

CML: chronic myeloid leukemia, GIPR: glucose-dependent insulinotropic polypeptide receptor, GLP-1R: glucagon-like peptide-1 receptor, NASH: non-alcoholic steatohepatitis, opt: optimization, PoC: proof of concept, THR-β: thyroid hormone receptor beta